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TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1
The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topoisomerase is covalently linked to the 3′- or 5′-terminus of a DNA strand break. This type of DNA damage is implicated in chromosome translocations and neurological disease and underlies the cl...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3458563/ https://ncbi.nlm.nih.gov/pubmed/22740648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks622 |
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