Targeted Deletion of Klotho in Kidney Distal Tubule Disrupts Mineral Metabolism

Renal Klotho controls mineral metabolism by directly modulating tubular reabsorption of phosphate and calcium and by acting as a co-receptor for the phosphaturic and vitamin D–regulating hormone fibroblast growth factor-23 (FGF23). Klotho null mice have a markedly abnormal phenotype. We sought to de...

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Detalles Bibliográficos
Main Authors: Olauson, Hannes, Lindberg, Karolina, Amin, Risul, Jia, Ting, Wernerson, Annika, Andersson, Göran, Larsson, Tobias E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Nephrology 2012
Assuntos:
Basic Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458458/
https://ncbi.nlm.nih.gov/pubmed/22878961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012010048
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