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Targeted Deletion of Klotho in Kidney Distal Tubule Disrupts Mineral Metabolism
Renal Klotho controls mineral metabolism by directly modulating tubular reabsorption of phosphate and calcium and by acting as a co-receptor for the phosphaturic and vitamin D–regulating hormone fibroblast growth factor-23 (FGF23). Klotho null mice have a markedly abnormal phenotype. We sought to de...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Nephrology
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3458458/ https://ncbi.nlm.nih.gov/pubmed/22878961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012010048 |
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