Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro

We describe a negative feedback autocrine regulatory circuit for glucose-stimulated insulin secretion in purified human islets in vitro. Using chronoamperometry and in vitro glucose-stimulated insulin secretion measurements, evidence is provided that dopamine (DA), which is loaded into insulin-conta...

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Detalhes bibliográficos
Main Authors: Simpson, Norman, Maffei, Antonella, Freeby, Matthew, Burroughs, Steven, Freyberg, Zachary, Javitch, Jonathan, Leibel, Rudolph L., Harris, Paul E.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458225/
https://ncbi.nlm.nih.gov/pubmed/22915827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1101
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