Ryanodine Receptor Blockade Reduces Amyloid-β Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium (Ca(2+)) homeostasis has been linked to presenilins, the catalytic core in γ-secretase complexes cleaving the amyloid precursor protein (APP), thereby generating amyloid-β (Aβ) peptides. Here we investigate whether...

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Main Authors: Oulès, Bénédicte, Del Prete, Dolores, Greco, Barbara, Zhang, Xuexin, Lauritzen, Inger, Sevalle, Jean, Moreno, Sebastien, Paterlini-Bréchot, Patrizia, Trebak, Mohamed, Checler, Frédéric, Benfenati, Fabio, Chami, Mounia
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458216/
https://ncbi.nlm.nih.gov/pubmed/22915123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0875-12.2012
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