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Evidence for Water-Tuned Structural Differences in Proteins: An Approach Emphasizing Variations in Local Hydrophilicity

We present experimental evidence for the significant effect that water can have on the functional structure of proteins in solution. Human (HSA) and Bovine Serum Albumin (BSA) have an amino acid sequence identity of 75.52% and are chosen as model proteins. We employ EPR-based nanoscale distance meas...

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Detalhes bibliográficos
Main Authors: Akdogan, Yasar, Reichenwallner, Jörg, Hinderberger, Dariush
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458090/
https://ncbi.nlm.nih.gov/pubmed/23049837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045681
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