A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer

OBJECTIVE: Early-onset colorectal cancer (CRC) represents a clinically distinct form of CRC that is often associated with a poor prognosis. Methylation levels of genomic repeats such as LINE-1 elements have been recognized as independent factors for increased cancer-related mortality. The methylatio...

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Autors principals: Antelo, Marina, Balaguer, Francesc, Shia, Jinru, Shen, Yan, Hur, Keun, Moreira, Leticia, Cuatrecasas, Miriam, Bujanda, Luis, Giraldez, Maria Dolores, Takahashi, Masanobu, Cabanne, Ana, Barugel, Mario Edmundo, Arnold, Mildred, Roca, Enrique Luis, Andreu, Montserrat, Castellvi-Bel, Sergi, Llor, Xavier, Jover, Rodrigo, Castells, Antoni, Boland, C. Richard, Goel, Ajay
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458035/
https://ncbi.nlm.nih.gov/pubmed/23049789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045357
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