c-Abl Inhibition Delays Motor Neuron Degeneration in the G93A Mouse, an Animal Model of Amyotrophic Lateral Sclerosis

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive death of motor neurons. Although the pathogenesis of ALS remains unclear, several cellular processes are known to be involved, including apoptosis. A previous study revealed the apoptosi...

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Hlavní autoři: Katsumata, Ryu, Ishigaki, Shinsuke, Katsuno, Masahisa, Kawai, Kaori, Sone, Jun, Huang, Zhe, Adachi, Hiroaki, Tanaka, Fumiaki, Urano, Fumihiko, Sobue, Gen
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458026/
https://ncbi.nlm.nih.gov/pubmed/23049975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046185
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