تحميل...
Use-dependent block of the voltage-gated Na(+) channel by tetrodotoxin and saxitoxin: Effect of pore mutations that change ionic selectivity
Voltage-gated Na(+) channels (NaV channels) are specifically blocked by guanidinium toxins such as tetrodotoxin (TTX) and saxitoxin (STX) with nanomolar to micromolar affinity depending on key amino acid substitutions in the outer vestibule of the channel that vary with NaV gene isoforms. All NaV ch...
محفوظ في:
| المؤلفون الرئيسيون: | , , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
The Rockefeller University Press
2012
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3457692/ https://ncbi.nlm.nih.gov/pubmed/23008436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201210853 |
| الوسوم: |
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