Prevalence and specificity of LKB1 genetic alterations in lung cancers

Germline LKB1 mutations cause Peutz–Jeghers syndrome, a hereditary disorder that predisposes to gastrointestinal hamartomatous polyposis and several types of malignant tumors. Somatic LKB1 alterations are rare in sporadic cancers, however, a few reports showed the presence of somatic alterations in...

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Bibliografiske detaljer
Main Authors: Matsumoto, S, Iwakawa, R, Takahashi, K, Kohno, T, Nakanishi, Y, Matsuno, Y, Suzuki, K, Nakamoto, M, Shimizu, E, Minna, JD, Yokota, J
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457639/
https://ncbi.nlm.nih.gov/pubmed/17384680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210418
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