Erythropoietin for Neuroprotection in Neonatal Encephalopathy: Safety and Pharmacokinetics

OBJECTIVE: To determine the safety and pharmacokinetics of erythropoietin (Epo) given in conjunction with hypothermia for hypoxic-ischemic encephalopathy (HIE). We hypothesized that high dose Epo would produce plasma concentrations that are neuroprotective in animal studies (ie, maximum concentratio...

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Autores principales: Wu, Yvonne W., Bauer, Larry A., Ballard, Roberta A., Ferriero, Donna M., Glidden, David V., Mayock, Dennis E., Chang, Taeun, Durand, David J., Song, Dongli, Bonifacio, Sonia L., Gonzalez, Fernando F., Glass, Hannah C., Juul, Sandra E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Academy of Pediatrics 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457622/
https://ncbi.nlm.nih.gov/pubmed/23008465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1542/peds.2012-0498
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