Abundant Drug-Resistant NS3 Mutants Detected by Deep Sequencing in Hepatitis C Virus-Infected Patients Undergoing NS3 Protease Inhibitor Monotherapy

The high genetic variation of hepatitis C virus (HCV) results in rapid selection of drug resistance mutations (DRMs) during monotherapy with direct-acting antivirals (DAAs). It has been proposed that each possible single mutant preexists in infected individuals; however, the levels of preexisting DR...

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Bibliographic Details
Main Authors: Svarovskaia, Evguenia S., Martin, Ross, McHutchison, John G., Miller, Michael D., Mo, Hongmei
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Virology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457457/
https://ncbi.nlm.nih.gov/pubmed/22837328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.00838-12
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