Mutation in the Plasmodium falciparum CRT Protein Determines the Stereospecific Activity of Antimalarial Cinchona Alkaloids

The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (−)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (−)-isomers in vitro and in vivo against Plasmodium falciparum malaria parasites. They may act by the inhibition of heme crys...

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Detalhes bibliográficos
Main Authors: Griffin, Carol E., Hoke, Jonathan M., Samarakoon, Upeka, Duan, Junhui, Mu, Jianbing, Ferdig, Michael T., Warhurst, David C., Cooper, Roland A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457399/
https://ncbi.nlm.nih.gov/pubmed/22869567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05667-11
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