Genome-Wide Compensatory Changes Accompany Drug- Selected Mutations in the Plasmodium falciparum crt Gene

Mutations in PfCRT (Plasmodium falciparum chloroquine-resistant transporter), particularly the substitution at amino acid position 76, confer chloroquine (CQ) resistance in P. falciparum. Point mutations in the homolog of the mammalian multidrug resistance gene (pfmdr1) can also modulate the levels...

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Detalhes bibliográficos
Main Authors: Jiang, Hongying, Patel, Jigar J., Yi, Ming, Mu, Jianbing, Ding, Jinhui, Stephens, Robert, Cooper, Roland A., Ferdig, Michael T., Su, Xin-zhuan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424241/
https://ncbi.nlm.nih.gov/pubmed/18575593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002484
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