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Peptide Interactions Stabilize and Restructure Human Papillomavirus Type 16 E6 To Interact with p53
Human papillomavirus type 16 (HPV-16) E6 (16E6) binds the E3 ubiquitin ligase E6AP and p53, thereby targeting degradation of p53 (M. Scheffner, B. A. Werness, J. M. Huibregtse, A. J. Levine, and P. M. Howley, Cell 63:1129–1136, 1990). Here we show that minimal 16E6-binding LXXLL peptides reshape 16E...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3457172/ https://ncbi.nlm.nih.gov/pubmed/22896608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01236-12 |
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