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Papillomavirus E6 PDZ Interactions Can Be Replaced by Repression of p53 To Promote Episomal Human Papillomavirus Genome Maintenance

Cancer-associated human papillomaviruses (HPVs) express E6 oncoproteins that target the degradation of p53 and have a carboxy-terminal PDZ ligand that is required for stable episomal maintenance of the HPV genome. We find that the E6 PDZ ligand can be deleted and the HPV genome stably maintained if...

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Hlavní autoři: Brimer, Nicole, Vande Pol, Scott B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958089/
https://ncbi.nlm.nih.gov/pubmed/24352452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02360-13
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