The Pre-NH(2)-Terminal Domain of the Herpes Simplex Virus 1 DNA Polymerase Catalytic Subunit Is Required for Efficient Viral Replication

The catalytic subunit of herpes simplex virus 1 DNA polymerase (HSV-1 Pol) has been extensively studied; however, its full complement of functional domains has yet to be characterized. A crystal structure has revealed a previously uncharacterized pre-NH(2)-terminal domain (residues 1 to 140) within...

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Autores principales: Terrell, Shariya L., Coen, Donald M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457154/
https://ncbi.nlm.nih.gov/pubmed/22875965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01034-12
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