Circumventing Antivector Immunity by Using Adenovirus-Infected Blood Cells for Repeated Application of Adenovirus-Vectored Vaccines: Proof of Concept in Rhesus Macaques

Adenovirus has been extensively exploited as a vector platform for delivering vaccines. However, preexisting antiadenovirus immunity is the major stumbling block for application of adenovirus-vectored vaccines. In this study, we found that freshly isolated peripheral blood mononuclear cells (PBMCs),...

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Dettagli Bibliografici
Autori principali: Sun, Caijun, Feng, Liqiang, Zhang, Yinfeng, Xiao, Lijun, Pan, Weiqi, Li, Chufang, Zhang, Linqi, Chen, Ling
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Gene Delivery
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457142/
https://ncbi.nlm.nih.gov/pubmed/22855499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00783-12
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