Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes.

Incubation of turkey erythrocytes with the phorbol ester phorbol 12-myristate 13-acetate (PMA) results in a dose- and time-dependent desensitization of isoproterenol-stimulated adenylate cyclase activity. Compared to controls, membranes from PMA-treated cells have an isoproterenol-stimulated adenyla...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Kelleher, D J, Pessin, J E, Ruoho, A E, Johnson, G L
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1984
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC345579/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6087317/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.14.4316
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