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Accuracy of Preimplantation Diagnosis of Single-Gene Disorders by Polar Body Analysis of Oocytes

Purpose:A number of pitfalls in single-cell DNA analysis, including undetected DNA contamination, undetected allele drop out, and preferential amplification, may lead to misdiagnosis in preimplantation genetic diagnosis of single-gene disorders. Methods:Preimplantation genetic diagnosis was performe...

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Detalhes bibliográficos
Main Authors: Rechitsky, S., Strom, C., Verlinsky, O., Amet, T., Ivakhnenko, V., Kukharenko, V., Kuliev, A., Verlinsky, Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Kluwer Academic Publishers-Plenum Publishers 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3455765/
https://ncbi.nlm.nih.gov/pubmed/10224562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1023/A:1020312823155
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