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Distinct loops in arrestin differentially regulate ligand binding within the GPCR opsin
G-protein-coupled receptors are universally regulated by arrestin binding. Here we show that rod arrestin induces uptake of the agonist all-trans-retinol in only half the population of phosphorylated opsin in the native membrane. Agonist uptake blocks subsequent entry of the inverse agonist 11-cis-r...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3455371/ https://ncbi.nlm.nih.gov/pubmed/22871814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2000 |
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