Chemically modified nucleic acids as immunodetectable probes in hybridization experiments.

Guanine residues in nucleic acids can be modified by treatment with N-acetoxy-N-2-acetylaminofluorene and its 7-iodo derivative in an in vitro nonenzymatic reaction. The modified nucleic acids (ribo or deoxyribo, single or double stranded) are recognized by specific antibodies. They can be immunopre...

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Bibliographic Details
Main Authors: Tchen, P, Fuchs, R P, Sage, E, Leng, M
Format: Artigo
Language:Inglês
Published: 1984
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC345529/
https://ncbi.nlm.nih.gov/pubmed/6374657
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