The development of novel quantification assay for mitochondrial DNA heteroplasmy aimed at preimplantation genetic diagnosis of Leigh encephalopathy

Purpose: To perform preimplantation genetic diagnosis (PGD) of Leigh encephalopathy, we developed a rapid and reliable quantification assay for the percentage of T8993G mtDNA mutation and analyzed various specimens. Methods: We prepared the standard curve by measuring serial proportion of 8993T/G cl...

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Autores principales: Tajima, Hiroto, Sueoka, Kou, Moon, Sung Yung, Nakabayashi, Akira, Sakurai, Tomoyoshi, Murakoshi, Yukitaka, Watanabe, Hiroyoshi, Iwata, Soukichi, Hashiba, Tsuyoshi, Kato, Shingo, Goto, Yu-Ichi, Yoshimura, Yasunori
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2007
Materias:
Genetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454964/
https://ncbi.nlm.nih.gov/pubmed/17342424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-007-9114-0
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