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Epigenetic regulation by decitabine of melanoma differentiation in vitro and in vivo
Apoptosis genes, such as TP53 and p16/CDKN2A, that mediate responses to cytotoxic chemotherapy, are frequently non-functional in melanoma. Differentiation may be an alternative to apoptosis for inducing melanoma cell cycle exit. Epigenetic mechanisms regulate differentiation, and DNA methylation alt...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3454528/ https://ncbi.nlm.nih.gov/pubmed/21796622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.26320 |
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