Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training

Aging promotes accumulation of reactive oxygen/nitrogen species (ROS/RNS) in cardiomyocytes, which leads to contractile dysfunction and cardiac abnormalities. These changes may contribute to increased cardiovascular disease in the elderly. Inducible antioxidant pathways are regulated by nuclear eryt...

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Main Authors: Gounder, Sellamuthu S., Kannan, Sankaranarayanan, Devadoss, Dinesh, Miller, Corey J., Whitehead, Kevin S., Odelberg, Shannon J., Firpo, Matthew A., Paine, Robert, Hoidal, John R., Abel, E. Dale, Rajasekaran, Namakkal S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454427/
https://ncbi.nlm.nih.gov/pubmed/23029187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045697
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