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In Vitro and In Vivo Antitumor Activity of a Novel pH-Activated Polymeric Drug Delivery System for Doxorubicin
BACKGROUND: Conventional chemotherapy agent such as doxorubicin (DOX) is of limited clinical use because of its inherently low selectivity, which can lead to systemic toxicity in normal healthy tissue. METHODS: A pH stimuli-sensitive conjugate based on polyethylene glycol (PEG) with covalently attac...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3454402/ https://ncbi.nlm.nih.gov/pubmed/23028490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044116 |
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