Targeting G with TAL Effectors: A Comparison of Activities of TALENs Constructed with NN and NK Repeat Variable Di-Residues

The DNA binding domain of Transcription Activator-Like (TAL) effectors can easily be engineered to have new DNA sequence specificities. Consequently, engineered TAL effector proteins have become important reagents for manipulating genomes in vivo. DNA binding by TAL effectors is mediated by arrays o...

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Main Authors: Christian, Michelle L., Demorest, Zachary L., Starker, Colby G., Osborn, Mark J., Nyquist, Michael D., Zhang, Yong, Carlson, Daniel F., Bradley, Philip, Bogdanove, Adam J., Voytas, Daniel F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454392/
https://ncbi.nlm.nih.gov/pubmed/23028976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045383
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