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Compound C Prevents the Unfolded Protein Response during Glucose Deprivation through a Mechanism Independent of AMPK and BMP Signaling

Inhibiting the unfolded protein response (UPR) can be a therapeutic approach, especially for targeting the tumor microenvironment. Here, we show that compound C (also known as dorsomorphin), a small-molecule inhibitor of AMP-activated protein kinase (AMPK) and bone morphogenetic protein (BMP) signal...

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Autors principals: Saito, Sakae, Furuno, Aki, Sakurai, Junko, Park, Hae-Ryong, Shin-ya, Kazuo, Tomida, Akihiro
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454318/
https://ncbi.nlm.nih.gov/pubmed/23029271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045845
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