Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in familial hypercholesterolemia heterozygotes: effects on cholesterol balance.

Patients with heterozygous familial hypercholesterolemia (FH) have a deficiency of receptors for plasma low-density lipoprotein (LDL) that impairs removal of LDL from plasma. In these patients, mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase [mevalonate:NAD+ oxidoreductase (CoA-a...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Grundy, S M, Bilheimer, D W
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1984
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC345098/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6371816/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.8.2538
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