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Class II HLA-DC beta-chain DNA restriction fragments differentiate among HLA-DR2 individuals in insulin-dependent diabetes and multiple sclerosis.

HLA-DR2 allele is negatively associated with insulin-dependent diabetes and positively associated with multiple sclerosis (MS). A 2.2-kilobase-pair EcoRI DNA restriction fragment detected with a beta-chain HLA-DC cDNA probe was found to be strongly correlated with HLA-DR2 in the normal population, b...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Cohen, D, Cohen, O, Marcadet, A, Massart, C, Lathrop, M, Deschamps, I, Hors, J, Schuller, E, Dausset, J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC345003/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6324215/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.6.1774
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