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Prolonged lidocaine metabolizing activity of primary hepatocytes with spheroid culture using polyurethane foam as a culture substratum

Primary rat hepatocytes formed spheroids in the pores of polyurethane foam (PUF) used as a culture substratum. The hepatocytes in monolayer and spheroid stationary culture converted lidocaine to monoethylglycinexylidide (MEGX) which was N-deethylation of lidocaine. The metabolic activity of the hepa...

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Bibliografiske detaljer
Main Authors: Nakazawa, Kohji, Matsushita, Taku, Funatsu, Kazumori
Format: Artigo
Sprog:Inglês
Udgivet: Kluwer Academic Publishers 1997
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449624/
https://ncbi.nlm.nih.gov/pubmed/22358767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1023/A:1007935016223
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