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On-line immunoanalysis of monoclonal antibodies during a continuous culture of hybridoma cells

The monoclonal-antibody production of an immobilized hybridoma cell line cultivated in a fluidized-bed reactor was monitored on-line for nearly 900 h. The monoclonal antibody concentration was determined by an immuno affinity-chromatography method (ABICAP). Antibodies directed against the product, e...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: van der Pol, Jens J., Machnik, Marc, Biselli, Manfred, Portela-Klein, Theresa, de Gooijer, Cornelis D., Tramper, Johannes, Wandrey, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Kluwer Academic Publishers 1997
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449612/
https://ncbi.nlm.nih.gov/pubmed/22358593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1023/A:1007913128209
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