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Long-term Continuous Production of Monoclonal Antibody by Hybridoma Cells Immobilized in a Fibrous-Bed Bioreactor
The kinetics and long-term stability of continuous production of monoclonal antibody IgG2b by hybridoma HD-24 cells immobilized in a fibrous-bed bioreactor (FBB) were studied for a period of ∼8 months. The cells were immobilized in the fibrous bed by surface attachment of cells and entrapment of lar...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Kluwer Academic Publishers
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3449501/ https://ncbi.nlm.nih.gov/pubmed/19003225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1023/B:CYTO.0000043395.36188.bc |
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