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Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

Breast cancers contain regions of intratumoral hypoxia in which reduced O(2) availability activates the hypoxia-inducible factors HIF-1 and HIF-2, which increase the transcription of genes encoding proteins that are required for many important steps in cancer progression. Recently, HIFs have been sh...

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Detalhes bibliográficos
Autor principal: Semenza, Gregg L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449282/
https://ncbi.nlm.nih.gov/pubmed/22921864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2012.08.001
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