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Mutagenesis Reveals Structure–Activity Parallels between Human A(2A) Adenosine Receptors and Biogenic Amine G Protein-Coupled Receptors
Structure–affinity relationships for ligand binding at the human A(2A) adenosine receptor have been probed using site-directed mutagenesis in the transmembrane helical domains (TMs). The mutant receptors were expressed in COS-7 cells and characterized by binding of the radioligands [(3)H]CGS21680, [...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
1997
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3449164/ https://ncbi.nlm.nih.gov/pubmed/9258366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm970084v |
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