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Benzodiazepines that bind at peripheral sites inhibit cell proliferation.

[3H]Ro5-4864 binds to mouse thymoma cells in a specific, saturable, and reversible manner. Scatchard analysis shows a single class of binding sites with a Kd of 4.4 nM and a Bmax of 477 fmol per 10(6) cells. This benzodiazepine binding site is of the peripheral type, based on the relative potencies...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wang, J K, Morgan, J I, Spector, S
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC344914/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6322168/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.3.753
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