Augmentation of cognitive function by NS9283, a stoichiometry-dependent positive allosteric modulator of α2- and α4-containing nicotinic acetylcholine receptors

BACKGROUND AND PURPOSE: Positive allosteric modulation of α4β2 nicotinic acetylcholine (nACh) receptors could add a new dimension to the pharmacology and therapeutic approach to these receptors. The novel modulator NS9283 was therefore tested extensively. EXPERIMENTAL APPROACH: Effects of NS9283 wer...

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Detalhes bibliográficos
Main Authors: Timmermann, DB, Sandager-Nielsen, K, Dyhring, T, Smith, M, Jacobsen, A-M, Nielsen, EØ, Grunnet, M, Christensen, JK, Peters, D, Kohlhaas, K, Olsen, GM, Ahring, PK
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448921/
https://ncbi.nlm.nih.gov/pubmed/22506660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01989.x
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