Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors

BACKGROUND AND PURPOSE: In mammalian cells, the anti-parasitic drug ivermectin is known as a positive allosteric modulator of the ATP-activated ion channel P2X4 and is used to discriminate between P2X4- and P2X7-mediated cellular responses. In this paper we provide evidence that the reported isoform...

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Detalhes bibliográficos
Main Authors: Nörenberg, W, Sobottka, H, Hempel, C, Plötz, T, Fischer, W, Schmalzing, G, Schaefer, M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448913/
https://ncbi.nlm.nih.gov/pubmed/22506590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01987.x
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