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Identification of FDA-approved drugs that computationally bind to MDM2
The integrity of the p53 tumor suppressor pathway is compromised in the majority of cancers. In 7% of cancers, p53 is inactivated by abnormally high levels of MDM2—an E3 ubiquitin ligase that polyubiquitinates p53, marking it for degradation. MDM2 engages p53 through its hydrophobic cleft and blocka...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3448857/ https://ncbi.nlm.nih.gov/pubmed/22703617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2012.01428.x |
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