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Constrained Bonding Environment in the Michaelis Complex of Trypanosoma cruzi Uridine Phosphorylase
The transition state for the Trypanosoma cruzi uridine phosphorylase (TcUP) reaction has an expanded S(N)2 character. We used binding isotope effects (BIE’s) to probe uridine distortion in the complex with TcUP and sulfate to mimic the Michaelis complex. Inverse 1′-(3)H and 5′-(3)H BIE’s indicate a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3448798/ https://ncbi.nlm.nih.gov/pubmed/22870934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300914q |
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