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Conditional Mesenchymal Disruption of Pkd1 Results in Osteopenia and Polycystic Kidney Disease
Conditional deletion of Pkd1 in osteoblasts using either Osteocalcin(Oc)-Cre or Dmp1-Cre results in defective osteoblast-mediated postnatal bone formation and osteopenia. Pkd1 is also expressed in undifferentiated mesenchyme that gives rise to the osteoblast lineage. To examine the effects of Pkd1 o...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3448720/ https://ncbi.nlm.nih.gov/pubmed/23029375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046038 |
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