Alternate-Week versus Continuous Dexamethasone Scheduling on the Risk of Osteonecrosis in Acute Lymphoblastic Leukemia: Results from the CCG-1961 Randomized Cohort Trial

BACKGROUND: Acute lymphoblastic leukemia (ALL) is curable in over 80% of children and adolescents with high-risk features. However, current therapies are associated with symptomatic osteonecrosis that disproportionately affects adolescents, often requires surgery, and is one of the most common cause...

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Autors principals: Mattano, Leonard A, Devidas, Meenakshi, Nachman, James B, Sather, Harland N, Hunger, Stephen P, Steinherz, Peter G., Gaynon, Paul S, Seibel, Nita L
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448283/
https://ncbi.nlm.nih.gov/pubmed/22901620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(12)70274-7
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