B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways

Recent data reveal an important role for B cells in the pathogenesis of chronic GVHD (cGVHD). Patients with cGVHD have delayed B-cell reconstitution and elevated BAFF to B-cell ratios compared to patients without cGVHD. The mechanisms promoting and sustaining B-cell activation in this disease, howev...

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Autori principali: Allen, Jessica L., Fore, Matthew S., Wooten, Jenna, Roehrs, Philip A., Bhuiya, Nazmim S., Hoffert, Todd, Sharf, Andrew, Deal, Allison M., Armistead, Paul, Coghill, James, Gabriel, Don A., Irons, Robert, Essenmacher, Amber, Shea, Thomas C., Richards, Kristy, Cutler, Corey, Ritz, Jerome, Serody, Jonathan, Baldwin, Albert S., Sarantopoulos, Stefanie
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2012
Soggetti:
Transplantation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448264/
https://ncbi.nlm.nih.gov/pubmed/22896003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-06-438911
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