cGMP-Compatible Preparative Scale Synthesis of Near-Infrared Fluorophores

Image-guided surgery using optical imaging requires the availability of large quantities of clinical-grade fluorophores. We describe the cGMP-compatible synthesis of the zwitterionic heptamethine indocyanine near-infrared fluorophore ZW800-1 at the 10-g scale (≈ 1,000 patient doses) using facile and...

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Main Authors: Hyun, Hoon, Bordo, Mark W., Nasr, Khaled, Feith, Dina, Lee, Jeong Heon, Kim, Soon Hee, Ashitate, Yoshitomo, Moffitt, Lorissa A., Rosenberg, Mireille, Henary, Maged, Choi, Hak Soo, Frangioni, John V.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448123/
https://ncbi.nlm.nih.gov/pubmed/22991318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmmi.1484
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