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cGMP-Compatible Preparative Scale Synthesis of Near-Infrared Fluorophores
Image-guided surgery using optical imaging requires the availability of large quantities of clinical-grade fluorophores. We describe the cGMP-compatible synthesis of the zwitterionic heptamethine indocyanine near-infrared fluorophore ZW800-1 at the 10-g scale (≈ 1,000 patient doses) using facile and...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3448123/ https://ncbi.nlm.nih.gov/pubmed/22991318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmmi.1484 |
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