Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat

Genome-wide association studies have identified SNPs reproducibly associated with type 2 diabetes (T2D). We examined the effect of genetic predisposition to T2D on insulin sensitivity and secretion using detailed phenotyping in overweight individuals with no diagnosis of T2D. Furthermore, we investi...

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Detalhes bibliográficos
Main Authors: Walker, Celia G., Loos, Ruth J. F., Mander, Adrian P., Jebb, Susan A., Frost, Gary S., Griffin, Bruce A., Lovegrove, Julie A., Sanders, Thomas A. B., Bluck, Les J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448035/
https://ncbi.nlm.nih.gov/pubmed/22350825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12263-012-0284-8
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