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A Nucleotide-Gated Molecular Pore Selects Sulfotransferase Substrates

Human SULT2A1 is one of two predominant sulfotransferases in liver and catalyzes transfer of the sulfuryl-moiety (-SO(3)) from activated sulfate (PAPS, 3′-phosphoadenosine 5-phosphosulfate) to hundreds of acceptors - metabolites and xenobiotics. Sulfation recodes the biologic activity of acceptors b...

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Autors principals: Cook, Ian, Wang, Ting, Falany, Charles N., Leyh, Thomas S.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448010/
https://ncbi.nlm.nih.gov/pubmed/22703301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300631g
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