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The structure of an As(III) S-adenosylmethionine methyltransferase: insights into the mechanism of arsenic biotransformation

Enzymatic methylation of arsenic is a detoxification process in microorganisms but in humans may activate the metalloid to more carcinogenic species. We describe the first structure of an As(III) S-adenosylmethionine methyltransferase by x-ray crystallography that reveals a novel As(III) binding dom...

詳細記述

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書誌詳細
主要な著者: Ajees, A. Abdul, Marapakala, Kavitha, Packianathan, Charles, Sankaran, Banumathi, Rosen, Barry P.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447999/
https://ncbi.nlm.nih.gov/pubmed/22712827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3004632
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