The Monoamine Re-Uptake Inhibitor UWA-101 Improves Motor Fluctuations in the MPTP-Lesioned Common Marmoset

BACKGROUND: The wearing-OFF phenomenon is a common motor complication of chronic L-3,4-dihydroxyphenylalanine (L-DOPA) therapy for Parkinson’s disease. We recently described the discovery of UWA-101, a dual serotonin (SERT) and dopamine (DAT) transporter inhibitor, which increases the duration of “g...

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Main Authors: Huot, Philippe, Johnston, Tom H., Gandy, Michael N., Reyes, M. Gabriela, Fox, Susan H., Piggott, Matthew J., Brotchie, Jonathan M
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447761/
https://ncbi.nlm.nih.gov/pubmed/23029119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045587
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