Biologic activity in a fragment of recombinant human interferon alpha.

To attempt to locate functionally important regions of the interferon (IFN) molecule, recombinant human IFN-alpha 2 was subjected to proteolytic digestion. The bacterial proteinase thermolysin produced two major complementary fragments, HuIFN-alpha 2-(1-110) and HuIFN-alpha 2-(111-153). After reduct...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ackerman, S K, Zur Nedden, D, Heintzelman, M, Hunkapiller, M, Zoon, K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1984
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC344760/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6199790/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.4.1045
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